Table of contents
Preface - E. Poryazova
Histological Sample preparation - N. Penkova, E. Poryazova11
Special /histochemical/ staining - D. Serteva
Immunohistochemical testing - E. Poryazova
Chapter I. General pathology
Reversible cell damage (acute and chronic) - E. Poryazova
Intracellular accumulation of pathologic substances - E. Poryazova17
Fig. 1 Hepatitis epidemiсa (viralis)
Fig. 2 Hydropic degeneration: renal tubular cells
Fig. 3 Degeneratio adiposa hepatis (steatosis hepatis)
Fig. 4 Degeneratio adiposa hepatis, Sudan III
Accumulation of pigments - E. Poryazova
Fig. 5 Anthracosis pulmonis
Fig. 6 Haemosiderosis pulmonis
Fig. 7 Haemosiderosis pulmonis, Perls
Fig. 8 Icterus hepatis
Fig. 9 Icterus renis
Accumulation of pathologic substances in the intercellular matrix - E. Poryazova
Fig. 10 Degeneratio mucoidea – Toluidin Blue
Fig. 11 Corpus albicans ovarii
Fig. 12 Hyalinosis arteriolarum renis
Fig. 13 Hypertonia arterialis benigna (cerebrum)
Fig. 14 Amyloidosis renis
Fig. 15 Amyloidosis renis, Congo rot
Fig. 16 Amyloidosis localis (glandulae mammae)
Fig. 17 Amyloidosis lienis
Fig. 18 Amyloidosis hepatis
Fig. 19 Tophi urici
Fig. 20 Calcificatio aortae
Compensatory-adaptive processes - N. Penkova, E. Poryazova
Fig. 21 Hypertrophia myocardii
4 Handbook of Histopathology and Immunohistochemistry
Fig. 22 Normal myocardium
Fig. 23 Hyperplasia mucosae uteri glandularis cystica
Fig. 24 Hyperplasia glandulae prostatae
Fig. 25 Atrophia fusca hepatis.
Fig. 26 Atrophia fusca myocardii
Fig. 27 Atrophia gl. Thyreoideae
Irreversible cell damage. Necrosis - I. Bivolarski
Fig. 28 Necrosis coagulativa lienis
Fig. 29 Necrosis colliquativa cerebri
Fig. 30 Steatonecrosis pancreatis
Fig. 31 Necrosis caseosa lymphonodi
Circulatory disorders - D. Serteva
Fig. 32 Cyanosis hepatic
Fig. 33 Hepar mouschatum
Fig. 34 Haemorrhagiae punctatae cerebri
Fig. 35 Oedema pulmonis
Fig. 36 Thrombus mixtus
Fig. 37 Embolia adiposa pulmonis, Sudan III
Fig. 38 Infarctus anaemicus renis
Fig. 39 Infarctus haemorrhagicus pulmonis
Inflammation - V. Belovejdov
Fig. 40 Pericarditis fibrinosa
Fig. 41 Leptomeningitis purulenta
Fig. 42 Appendicitis phlegmonosa
Fig. 43 Myocarditis acuta abscedens.
Fig. 44 Granulatio
Fig. 45 Polypus nasalis
Fig. 46 Granuloma typus corporis alieni
Fig. 47 Echinococcus hepatis
Fig. 48 Chitin and germinative membranes (Echinococcus cyst)
Fig. 49 Lymphadenitis granulomatosa
Fig. 50 Langhans giant cell
Fig. 51 Mesaortitis luetica
Fig. 52 Actinomycosis
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Regeneration and fibrosis - D. Serteva
Fig. 53 Cicatrix myocardii.
Fig. 54 Cicatrix myocardii-Van Gieson
Fig. 55 Regeneratio medullae ossea
Tumours - E. Poryazova
Fig. 56 Lipoma
Fig. 57 Haemangioma cavernosum hepatis
Fig. 58 Haemangioma capillarae cutis
Fig. 59 Leiomyoma uteri
Fig. 60 Leiomyosarcoma
Fig. 61 Teratoma adultum
Fig. 62 Carcinoma basocellulare
Fig. 63 Squamous cell papilloma
Fig. 64 Carcinoma planocellulare keratodes
Fig. 65 Carcinoma planocellulare nonkeratodes
Fig. 66 Undifferentiated carcinoma
Fig. 67 Normal skin
Fig. 68 Merkel cell carcinoma
Fig. 69 Naevus pigmentosus
Fig. 70 Melanoma malignum.
Fig. 71 Lymphogenous tumour embolism
Fig. 72 Perineural invasion (adenocarcinoma
Fig. 73 Angiosarcoma
Fig. 74 Rabdomyosarcoma
Fig. 75 В-cell malignant lymphoma
Chapter II. Clinical pathology
Respiratory system - V. Belovejdov
Fig. 76 Normal lung
Fig. 77 Lung of newborn (with intraalveolar hemorrhages)
Fig. 78 Bronchitis chronica
Fig. 79 Emphysema pulmonis
Fig. 80 Pneumonia crouposa
Fig. 81 Silicosis pulmonis
Fig. 82 Carcinoma pulmonis planocellulare keratodes
6 Handbook of Histopathology and Immunohistochemistry
Fig. 83 Carcinoma adeno-squamosus pulmonis
Fig. 84 Carcinoma pulmonis parvocellulare
Cardiovascular system - E. Poryazova
Fig. 85 Atherosclerosis aortae
Fig. 86 Endocarditis verrucosa
Fig. 87 Normal myocardium.
Fig. 88 Infarctus myocardii recens
Fig. 89 Myocarditis reumatica
Autoimmune diseases and connective tissue disorders - D. Serteva
Fig. 90 Struma lymphomatosa (Hashimoto thyroiditis)
Fig. 91 Polyartheriitis nodosa
Fig. 92 Polyarthritis rheumatoides
Hemato / lymphopoietic system - N. Penkova, E. Poryazova
Fig. 93 Normal spleen
Fig. 94 Normal thymus
Fig. 95 Normal liver
Fig. 96 Lymphadenosis leucaemica hepatis
Fig. 97 Myelosis leucaemica hepatis
Fig. 98 Follicular hyperplasia (lymph node)
Fig. 99 Lymphoma malignum typus non Hodgkin
Fig. 100 Morbus Hodgkin (Lymphogranulomatosis maligna)
Fig. 101 Plasmocytoma
Digestive system - E. Poryazova
Fig. 102 Gingivitis chronica hypertroficans
Fig. 103 Stomatitis candidosa
Fig. 104 Leucoplakia
Fig. 105 Epulis gigantocellularis
Fig. 106 Carcinoma planocellulare linguae
Fig. 107 Cysta radicularis
Fig. 108 Sialoadenitis chronica
Fig. 109 Amelloblastoma (Adamantinoma)
Fig. 110 Adenoma pleomorphae glandulae parotis
Fig. 111 Adenolymphoma, Warthin’s tumor
Fig. 112 Tonsilitis chronica (hypertroficans)
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Pathological changes of the stomach - E. Poryazova
Fig. 113 Gastritis chronica atrophicans
Fig. 114 Ulcus acutum duodeni
Fig. 115 Ulcus chronicum ventriculi exacerbate
Fig. 116 Adenocarcinoma ventriculi
Fig. 117 Signet ring cell carcinoma
Pathological changes of the small and large intestines - E. Poryazova
Fig. 118 Colitis chronica
Fig. 119 Tubular adenoma (large colon)
Fig. 120 Adenomatous polyp (with high-grade dysplasia)
Fig. 121 Adenocarcinoma of colon (moderately differentiated)
Fig. 122 Adenocarcinoma gellatinosum (colon), PAS
Fig. 123 Carcinoid tumour, (small intestine)
Pathological changes of the liver, gall bladder and exocrine pancreas - E. Poryazova100
Fig. 124 Hemangiosarcoma hepatis
Fig. 125 Cirrhosis hepatis micronodularis
Fig. 126 Cholecystitis chronica
Endocrine system - V. Belovejdov
Fig. 127 Struma colloides
Fig. 128 Struma Basedowiana
Fig. 129 Carcinoma papillare gl. thyreoideae
Fig. 130 Glomerulosclerosis diabetica
Kidney and urinary tract - I. Bivolarski
Fig. 131 Normal kidney
Fig. 132 Glomerulonephritis semilunaris (subacuta)
Fig. 133 Glomerulonephritis mesangiocapillaris
Fig. 134 Nephrosclerosis glomerulonephritica
Fig. 135 Pyelonephritis acuta abscedens
Fig. 136 Pyelonephritis chronica
Fig. 137 Carcinoma renis
Fig. 138 Carcinoma vesicae urinariae
Female reproductive system - E. Poryazova
8 Handbook of Histopathology and Immunohistochemistry Diseases related to pregnancy - E. Poryazova
Fig. 139 Abortus
Fig. 140 Decidua
Fig. 141 Arias-Stella reaction
Fig. 142 Mola hydatidosa
Fig. 143 Choriocarcinoma (chorionepithelioma)
Diseases of the cervix - V. Belovejdov
Uterine body and endometrium disorders - E. Poryazova
Fig. 144 Hyperplasia mucosae uteri glandularis cystica
Fig. 145 Atypical endometrial hyperplasia
Fig. 146 Endometriosis
Fig. 147 Adenocarcinoma corporis uteri
Inflammatory and tumour disorders of the ovaries - E. Poryazova
Fig. 148 Cystadenoma papilliferum serosum ovarii
Fig. 149 Cystadenocarcinoma papilliferum serosum ovarii
Mammary gland disorders - E. Poryazova
Fig. 150 Fibrosis cystica glandulae mammae
Fig. 151 Fibroadenoma glandulae mammae
Fig. 152 Carcinoma ductale glandulae mammae
Fig. 153 Carcinoma scirrhosum
Male reproductive system - D. Serteva
Fig. 154 Carcinoma glandulae prostate
Fig. 155 Atrophic testis
Fig. 156 Seminoma testis
Fig. 157 Yolk sac tumor (tumor of Teilum)
Nervous system - E. Poryazova
Fig. 158 Polioencephalitis acuta
Fig. 159 Poliomyelitis anterior acuta
Tumours of the nervous system - E. Poryazova
Fig. 160 Astrocytoma
Fig. 161 Glioblastoma multiforme
Fig. 162 Neurinoma (schwanoma)
Fig. 163 Meningioma
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CHAPTER III. Immunohistochemical testing
Reading the results of the IHC test - E. Poryazova
IHC-markers for proving the histogenesis of tumours - E. Poryazova
Fig. 164 IHC-testing, Cytokeratin
Fig. 165 IHC-testing ,Cytokeratin 20140
Fig. 166 IHC-testing, Cytokeratin 71
Fig. 167 IHC-testing, Vimentin
Fig. 168 IHC-testing, S-100 protein , Х100
Fig. 169 IHC-testing, СЕА
Fig. 170 IHC-testing, S-100 protein
Fig. 171 IHC-testing, Desmin
Fig. 172 IHC-testing, CD 117
Fig. 173 IHC-testing, CDX2
Fig. 174 IHC-testing, Chromogranin A
Fig. 175 IHC-testing, CD20
Fig. 176 IHC-testing, CD3
Fig. 177 IHC-testing, Factor VIII
IHC-markers for detecting the proliferative activity of tumours - E. Poryazova
Fig. 178 IHC-testing, Ki-67
Fig. 179 IHC-testing, Ki-67
Fig. 180 IHC-testing, p-53
Fig. 180 IHC-testing, p-53
Fig. 182 IHC-testing, p-53
Fig. 183 IHC-testing, E –Cadherin
Fig. 184 IHC-testing, Beta-catenin
Fig. 185 IHC-testing, AMACR
Fig. 186 IHC-testing, AMACR
IHC-testing of the hormone receptors and the antigens of growth factorsm - E. Poryazova151
Fig. 187 IHC-testing, ЕR
Fig. 188 IHC-testing, РR
Fig. 189 IHC-testing, Her 2
Fig. 190 IHC-testing, Her 2
Index